Clinical, morphological and diagnostic characteristics of malignant mammary tumor in bitches

Autores

  • Ciro José Sousa de Carvalho
  • Airton Mendes Conde Junior
  • Silvia de Araújo França Baêta
  • Francisco de Assis Leite Souza
  • Salviano Tramontin Belettini
  • Natalie Bertelis Merlini
  • Luan Vinícius Tezzei Maia
  • Ana Maria Quessada Universidade Paranaense

DOI:

https://doi.org/10.53660/325.prw813a

Palavras-chave:

Adenocarcinoma, Canine, Mammary neoplasia, Cytology

Resumo

Mammary tumor is the most frequent neoplasia in bitches in Brazil, and most of the mammary tumors in female dogs in the country, are malignant. This study aimed to evaluate clinical, morphological and diagnostic characteristics of malignant mammary tumors in 32 bitches. The average age of the bitches was 10.1 years, demonstrating that older bitches are more predisposed. Most bitches weren't neutered. Tumor size in most animals was greater than 5 cm. and showed rapid growth in most cases. In all bitches, no signs of metastases in the lungs were observed. The results of the cytological exams showed a mixed malignant tumor and adenocarcinoma, and about 81.5% of adenocarcinomas were confirmed by histopathological exam. It was concluded that non-castrated elderly female dogs were the majority. Malignant tumors larger than 5 cm with fast growth and firm consistency were the most frequent.

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Referências

ANDRADE, R.L.F.S.; OLIVEIRA, D.M.; DANTAS, A.F.M. et al. Tumores de cães e gatos diagnosticados no semiárido da Paraíba. Pesquisa Veterinária Brasileira, v.32, n.10, p.1037-1040, 2014. Avaliable from: http://www.pvb.com.br/antigo/pdf_artigos/01-10-2012_10-42Vet%201279_2803%20PA.pdf.

ANTUNES, M.I.P.P.; MORENO, K.; GRUMADAS, C.E.S. Avaliação e manejo da dor em cães e gatos com câncer – revisão. Arquivos de Ciências Veterinárias e Zoologia da Unipar., v.11, n.2, p.113-119, 2008. Avaliable from: https://ojs.revistasunipar.com.br/index.php/veterinaria/article/view/2567/1995.

BIONDI, L.R.; GENTILE, L.B. REGO, A.A.M.S.; NORONHA, N.P.; DAGLI, M.L.Z. Canine mammary tumors in Santos, Brazil: clinicopathological and survival profile. Brazilian Journal of Veterinary Research and Animal Science, v. 51, n. 3, p. 252- 262, 2014. Avaliable from: https://doi.org/10.11606/issn.1678-4456.v51i3p252-262

CASSALI, G. D. Patologias da glândula mamária. In: NASCIMENTO, E.F. SANTOS, R.L. Patologia da Reprodução dos animais domésticos. v. 2, n.2, p. 119 – 133, 2000.

CASSALI, G.D.; LAVALLE, G. E.; DE NARDI, A. B.; FERREIRA, E.; BERTAGNOLLI, A. C.; ESTRELA-LIMA, A. et al. Consensus for Diagnosis, Prognosis and Treatment of Canine Mammary Tumors. Brazilian Journal of Veterinary Pathololgy, v. 4, n. 2, p. 153-80, 2011. Avaliable from: https://repositorio.ufba.br/bitstream/ri/5386/1/Consenso.pdf.

CASSALI, G.D.; JARK, P.C.; GAMBA, C.; DAMASCENO, K.A.; ESTRELA-LIMA, A.; DE NARDI, A.B.; FERREIRA, E.; HORTA, R.S.; FIRMO, F.A.R.; SUEIRO, F.A.R.; RODRIGUES, L.C.S.; NAKAGAKI, K.Y.R. Consensus regarding the diagnosis, prognosis and treatment of canine and feline mammary tumors - 2019. Brazilian Journal of Veterinary Pathology, v.13, n.3, p.555-574, 2020. Avaliable from: http://bjvp.org.br/wp-content/uploads/2020/11/v13-n3-1.pdf.

CAVALCANTI, M.F.; CASSALI, G.D. Fatores prognósticos no diagnóstico clínico e histopatológico dos tumores de mama em cadelas – revisão. Revista Clínica Veterinária, v.61, p.56-63, 2006.

DALECK, C. R.; NARDI, A. B.; RODASKI, S. Oncologia em Cães e Gatos. São Paulo: ROCCA, 2009. 612 p.

DIAS, M.L.M.; ANDRADE, J.M.L.; CASTRO, M.B.; GALERA, P.D. Survival analysis of female dogs with mammary tumors after mastectomy: epidemiological, clinical and morphological aspects. Pesquisa Veterinária Brasileira, v.36, n.3, p.181-186, 2016. Avaliable from: https://web.archive.org/web/20180727095121id_/http://www.scielo.br/pdf/pvb/v36n3/1678-5150-pvb-36-03-00181.pdf

ESTRELA-LIMA, A.; ARAÚJO, M.S.S.; COSTA-NETO, J.M.; TEIXEIRA-CARVALHO, A.; BARROUIN-MELO, S.M.; CARDOSO, S.V.; MARTINS-FILHO, A.O.; SERAKIDES, R.; CASSALI, G.D. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC Cancer, 10:256-270, 2010. Avaliable from: https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-256

FELICIANO, M.A.R., SILVA, A. S., PEIXOTO, R. V. R.; GALERA, P. D.; VICENTE, W. R. R. Estudo clínico, histopatológico e imunoistoquímico de neoplasias mamárias em cadelas. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.64, n.5, p.1094-1100, 2012. Avaliable from: https://doi.org/10.1590/S0102-09352012000500002

KAMIGUCHI, I.E.; MOREIRA, I.M.; TRINDADE, F.S.; ZAHN, F.S.; HATAKA, A.; ROCHA, N.S. Mammary Neoplasms in Female Dogs: Identification of Cytopathological Criteria for Malignancy. Journal of Cytology and Histology, v.7, n.1, p. 2016. Avaliable from: http://dx.doi.org/10.4172/2157-7099.1000392

KRISTIANSEN, V.M.; PEÑA, L.; DÍEZ CÓRDOVA, L.; ILLERA, J.C.; SKJERVE, E.; BREEN, A.M.; COFONE, M.A.; LANGELAND, M.; TEIGE, J.; GOLDSCHMIDT, M.; SØRENMO, K.U. Effect of ovariohysterectomy at the time of tumor removal in dogs with mammary carcinomas: a randomized crontrolled trial. Journal of Veterinary Internal Medicine, v.30, p.230-241, 2016. Avaliable from: https://doi.org/10.1111/jvim.13812

LANA, S.E.; RUTTEMAN, G.R.; WITHROW, S.J. Tumors of the mammary gland. In: WITHROW, S.J. e VAIL, D.M. (Eds). Withrow e MacEwen's Small Animal Clinical Oncology. 4.e. St. Louis: Saunders Elsevier, 2007. p.619-636.

MAGALHÃES, C.S.; LIMA, W.C.; LIMA, D.A.S.D.; QUESSADA, A.M.; DORNELLES, D.E.M.; COSTA NETO, J.M. Conhecimento de tutores de cães sobre tumor de mama em cadelas. Acta veterinária brasílica, v 10, n.2, p.186-189, 2016. Avaliable from: https://doi.org/10.21708/avb.2016.10.2.5537

MAGALHÃES, J.R.; GUIMARÃES, J.B.; BONFIM, L.S.; CARVALHO, C.L.; LUZ, L.C.; CAGNINI, D.Q.; REGALIN, D.; AMARAL, A.V.C. Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia. Pesquisa Veterinária Brasileira, v.40, n.7, p. 536-545, 2020. Avaliable from: https://doi.org/10.1590/1678-5150-PVB-6451

MISDORP, W.; ELSE, R.W.; HELLMÉN, E.; LIPSCOMB, T.P. Histological classification of mammary tumors of the dog and cat. Washington DC: Armed Force Institute of Pathology, 1999. 59 p.

MISDORP, W. Tumors of the mammary gland. In: MEUTEN, D.J. (Ed.) Tumors in Domestic Animals. Iowa State: University of California., 2002. p. 575-606.

NUNES, F.C.; CAMPOS, C.B.; TEIXEIRA, S.V.; BERTAGNOLLI, A.C.; LAVALLE, G.E.; CASSALI, G.D. Epidemiological, clinical and pathological evaluation of overall survival in canines with mammary neoplasms. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 70, n.6, p. 1714-1722, 2018. Avaliable from: https://doi.org/10.1590/1678-4162-10217

OLIVEIRA FILHO, J.C.O.; KOMMERS, G.D.; MASUDA, E.K.; MARQUES, B.M.F.P.P.; FIGHERA, R.A.; IRIGOYEN, L.F.; BARROS, C.S.L. Estudo retrospectivo de 1.647 tumores mamários em cães. Pesquisa Veterinária Brasileira, v.30, n.2, p.177-185, 2010. Avaliable from: http://www.pvb.com.br/antigo/pdf_artigos/01-03-2010_01-11Vet786.pdf.

OLIVEIRA, J.T.; PINHO, S.S.; MATOS, A.J.; HESPANHOL, V.; REIS, C.A.; GARTNER, F. MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features. The Veterinary Journal v. 182, p. 491-493, 2009. Avaliable from: https://doi.org/10.1016/j.tvjl.2008.09.007

OLIVEIRA, G.S.O.; PANDOLFI, I.A. Estudo retrospectivo dos exames histopatológicos realizados em cadelas com tumores mamários em hospital veterinário. PUBVET, v. 14, p. 163, 2020. Avaliable from: https://doi.org/10.31533/pubvet.v14n8a634.1-8

PELETEIRO, M.C. Tumores mamários na cadela e na gata. Revista Portuguesa de Ciências Veterinárias, v.89, p.10-29, 1994.

RIBAS, C.R.; DORNBUSCH, P.T.; FARIA, M.R.; FIGUEIREDO, W.A.F.P.; CIRIO, S.M. Alterações clínicas relevantes em cadelas com neoplasias mamárias estadiadas. Archives of Veterinary Science, v.17, n.1, p.60-68, 2012.

SANTOS, T.R.; CASTRO, J.R.; ANDRADE, J.C.; SILVA, A.C.R.; SILVA, G.M.F.; FERREITA, F.A., HEADLEY, S.; SAUT, J.P. Fatores de risco para tumores mamários em cadelas de Uberlândia e Patos de Minas, Minas Gerais. Pesquisa Veterinária Brasileira, v. 40, n. 6, p. 466-473, 2020. Avaliable from: https://doi.org/10.1590/1678-5150-PVB-6360.

SILVA, A.H.C.; SILVA, D.M.; RIBAS, C.R.; DITRICH, R.L.; DORNBUSCH, P.T.; GUÉRIOS, S.D. Alterações no hemograma de cadelas com neoplasia mamária. Ciencia animal brasileira, v.15, n.1, p. 87-92, 2014. Avaliable from: 10.5216/cab.v15i1.20144

SORENMO, K. U.; WORLEY, D.R.; GOLDSCHMIDT, M.H. Tumors of the mammary gland. In: WITHROW, S.J.; VAIL, D.M.; PAGE, R.P. Withrow and MacEwen’s Small Animal Clinical Oncology, 5.ed. Philadelphia: Saunders Company, 2013, cap.27, p.538-556.

TORÍBIO, J.M.M.L.; LIMA, A. E.; FILHO, E. F. M.; RIBEIRO, L. G. R.; D’ASSIS, M. J. M. H.; TEXEIRA, R. G.; DAMASCENO, K. A.; CASSALI, G. D.; NETO, J. M. C. Caracterização clínica, diagnóstico histopatológico e distribuição geográfica das neoplasias mamárias em cadelas de Salvador, Bahia. Revista Ceres, v. 59, n.4, p. 427-433, 2012. Avaliable fom: https://web.archive.org/web/20170818222725id_/http://www.redalyc.org/pdf/3052/305226898001.pdf.

VASCONCELOS, A.C. Patologia Geral em Hipertexto. Universidade Federal de Minas Gerais. Belo Horizonte, Minas Gerais, 2000. Avaliable from: http://depto.icb.ufmg.br/dpat/old/pathip.htm

VARMA, C.G.; TEJA, LAVANYA, K. Assessment of risk factors for incidence of canine mammary tumors. The Pharma Innovation Journal. v.10, n.5, p.554-556, 2021. Avaliable from: https://www.thepharmajournal.com/archives/2021/vol10issue5/PartH/10-4-175-524.pdf.

VITAL, A.; SANTILLI, J.; SOBREIRA, M.; ANDRADE, K.; CALAZANS, S. Contagem de plaquetas em cadelas com carcinoma mamário. Revista Investigação, v. 14, n. 3, p. 12-15., 2015. Avaliable from: https://doi.org/10.26843/investigacao.v14i3.939.

Publicado

2023-04-25

Como Citar

Carvalho, C. J. S. de ., Conde Junior, A. M. ., Baêta, S. de A. F. ., Souza, F. de A. L. ., Belettini, S. T. ., Merlini, N. B. ., Maia, L. V. T., & Quessada, A. M. (2023). Clinical, morphological and diagnostic characteristics of malignant mammary tumor in bitches. Peer Review, 5(5), 366–378. https://doi.org/10.53660/325.prw813a

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