Expressão diferencial no Lúpus Eritematoso Sistêmico sugere disfunção no mecanismo de produção de energia mitocondrial
DOI:
https://doi.org/10.53660/PRW-2446-4438Palavras-chave:
Biomarcadores, Estresse Oxidativo, Fosforilação Oxidativa, Mitocôndria, LúpusResumo
O Lúpus Eritematoso Sistêmico (LES) é uma das doenças autoimunes mais incidentes no mundo, mas há pouca clareza no que diz respeito ao seu aspecto patológico. À vista disso, estudos de novas vias se fazem necessários, como a influência mitocondrial nesta doença. Assim, este trabalho visou realizar a análise de expressão diferencial (AED) de genes nucleares de função mitocondrial no LES. Tratou-se de um estudo observacional descritivo in silico utilizando dados públicos de sequenciamento completo de RNA. Diante disso, foram encontrados três genes diferencialmente expressos (GDE) hipoexpressos (CDS1, SARDH e NIPSNAP3B), enquanto dois (TYMS e SCO2) estivam hiperexpressos. Em relação aos genes hipoexpressos, estes não foram datados em relação ao LES na literatura até esta pesquisa. Os genes hiperexpressos já foram associados às condições do LES e podem representar marcadores do estresse oxidativo causado pelo aumento da Fosforilação Oxidativa nestes indivíduos. Representa-se aqui cinco novos genes a serem considerados como possíveis biomarcadores genéticos mitocondriais no LES.
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