Efeito da suplementação de alimentos funcionais no músculo esquelético de ratos expostos cronicamente ao tabagismo
DOI:
https://doi.org/10.53660/1385.prw2912Palavras-chave:
Probiótico, Prebiótico, Simbiótico, Gastrocnêmio, Dimensão fractalResumo
O objetivo foi avaliar o efeito da suplementação oral de probiótico, prebiótico e simbiótico no tecido muscular esquelético, gastrocnêmio, de ratos expostos ao tabagismo, através da dimensão fractal (DF). Sessenta e quatro ratos foram aleatoriamente alocados em 8 grupos (n=8): com ração controle (C) ou suplementadas com probiótico (Pro), prebiótico (Pre) ou simbiótico (Simb) e os quatro grupos foram alimentados com as rações C, Pro, Pre e Simb e expostos ao tabagismo. Após 180 dias de experimento, os animais foram anestesiados, sacrificados e os músculos gastrocnêmios foram submetidos a procedimento histológico de rotina e corados pela técnica de HE. As imagens dos cortes histológicos foram capturadas e submetidas à análise da DF. Os dados foram submetidos à análise de variância, seguida do teste de Tukey. Os resultados revelaram que a suplementação de probiótico, prebiótico e simbióticos atenuaram os efeitos deletérios da exposição crônica a fumaça do cigarro (p<0,05). Os resultados permitem concluir que a suplementação de probiótico, prebiótico e simbiótico atenuam os efeitos deletérios da exposição crônica e passiva a fumaça do cigarro em ratos machos jovens, como modelo pré-clínico.
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