Treinamento físico na melhora da função endotelial de mulheres com câncer de mama: uma revisão sistemática

Autores

DOI:

https://doi.org/10.53660/PRW-2672-4827

Palavras-chave:

Exercício físico, Função endotelial, Câncer de mama

Resumo

Este estudo consistiu em uma revisão sistemática, realizada seguindo as diretrizes PRISMA e incluindo ensaios clínicos randomizados e estudos piloto, com o objetivo de investigar os efeitos dos exercícios físicos na função endotelial de mulheres com câncer de mama. Foram incluídos quatro estudos clínicos, totalizando 133 participantes, com intervenções que variaram entre exercícios aeróbicos e treinamento intervalado de alta intensidade (HIIT). As avaliações da função endotelial foram realizadas utilizando a dilatação mediada por fluxo (FMD) e o índice de hiperemia reativa (RHI), ambos indicativos da saúde vascular. A maioria dos estudos relatou melhorias significativas na função endotelial e na capacidade cardiorrespiratória, especialmente em protocolos de maior duração e intensidade, sugerindo benefícios dos exercícios no contexto oncológico. Contudo, a heterogeneidade metodológica entre os estudos limitou a generalização das conclusões, evidenciando a necessidade de mais pesquisas para elucidar esses efeitos de forma mais robusta.

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Referências

ANASTASIOU, Maria et al. Prolonged impact of anti-cancer therapy on endothelial function and arterial stiffness in breast cancer patients. Vascular Pharmacology, v. 152, p. 107195, 2023.

ARMENIAN, Saro H. et al. Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study. Journal of Clinical Oncology, v. 34, n. 10, p. 1122, 2016.

ASHOR, Ammar W. et al. Exercise modalities and endothelial function: a systematic review and dose–response meta-analysis of randomized controlled trials. Sports medicine, v. 45, p. 279-296, 2015.

BEAUDRY, Rhys I. et al. Meta-analysis of exercise training on vascular endothelial function in cancer survivors. Integrative Cancer Therapies, v. 17, n. 2, p. 192-199, 2018.

BOENO, Francesco P. et al. Effect of aerobic and resistance exercise training on inflammation, endothelial function and ambulatory blood pressure in middle-aged hypertensive patients. Journal of hypertension, v. 38, n. 12, p. 2501-2509, 2020.

BRADSHAW, Patrick T. et al. Cardiovascular disease mortality among breast cancer survivors. Epidemiology, v. 27, n. 1, p. 6-13, 2016.

BRUNO, Rosa Maria; GORI, Tommaso; GHIADONI, Lorenzo. Endothelial function testing and cardiovascular disease: focus on peripheral arterial tonometry. Vascular health and risk management, p. 577-584, 2014.

DE SOUZA, Juliana Andrade Ferreira et al. Effect of exercise on endothelial function in heart transplant recipients: systematic review and meta-analysis. Heart Failure Reviews, v. 25, p. 487-494, 2020.

DI FRANCESCOMARINO, Samanta et al. The effect of physical exercise on endothelial function. Sports medicine, v. 39, p. 797-812, 2009.

FUERTES-KENNEALLY, Laura et al. Effects and optimal dose of exercise on endothelial function in patients with heart failure: a systematic review and meta-analysis. Sports Medicine-Open, v. 9, n. 1, p. 8, 2023.

GEVAERT, Andreas B. et al. Effect of training on vascular function and repair in heart failure with preserved ejection fraction. Heart Failure, v. 11, n. 4, p. 454-464, 2023.

GIALLAURIA, Francesco et al. Exercise training improves cardiopulmonary and endothelial function in women with breast cancer: findings from the Diana-5 dietary intervention study. Internal and emergency medicine, v. 11, p. 183-189, 2016.

GONG, Xiaodan; HU, Mengwen; LI, Mei. Relationship of arterial tonometry and exercise in patients with chronic heart failure: a systematic review with meta-analysis and trial sequential analysis. BMC Cardiovascular Disorders, v. 22, n. 1, p. 345, 2022.

HAJJAR, Ludhmila Abrahão; COSTA, Isabela Bispo Santos da Silva; LOPES, Marcelo Antônio Cartaxo Queiroga, et al. Diretriz Brasileira de Cardio-oncologia–2020. Arquivos Brasileiros de Cardiologia, v. 115, p. 1006-1043, 2020.

HERRMANN, Joerg. Vascular toxic effects of cancer therapies. Nature Reviews Cardiology, v. 17, n. 8, p. 503-522, 2020.

INABA, Yoichi; CHEN, Jennifer A.; BERGMANN, Steven R. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. The international journal of cardiovascular imaging, v. 26, p. 631-640, 2010.

JONES, Lee W. et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prevention Research, v. 6, n. 9, p. 925-937, 2013.

KOUTROUMPI, Matina et al. Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects. World Journal of Cardiology, v. 4, n. 12, p. 312, 2012.

LEE, Kyuwan et al. Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study. Breast cancer research and treatment, v. 177, p. 477-485, 2019.

MAYR, Barbara et al. The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy. Cancer Medicine, v. 11, n. 24, p. 4946-4953, 2022.

MCGUINNESS, L. A.; HIGGINS, J. P. T. Risk-of-bias VISualization (robvis): um pacote R e aplicativo web Shiny para visualizar avaliações de risco de viés. Research Synthesis Methods, v. 1, p. 1-7, 2020. https://doi.org/10.1002/jrsm.1411.

PARR, Shannon K. et al. Anticancer Therapy–Related Increases in Arterial Stiffness: A Systematic Review and Meta‐Analysis. Journal of the American Heart Association, v. 9, n. 14, p. e015598, 2020.

PATTYN, Nele et al. The long-term effects of a randomized trial comparing aerobic interval versus continuous training in coronary artery disease patients: 1-year data from the SAINTEX-CAD study. European journal of preventive cardiology, v. 23, n. 11, p. 1154-1164, 2016.

PEARSON, M. J.; SMART, N. A. Aerobic training intensity for improved endothelial function in heart failure patients: a systematic review and meta‐analysis. Cardiology research and practice, v. 2017, n. 1, p. 2450202, 2017.

PEDRALLI, Marinei L. et al. Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: A randomized clinical trial. Scientific reports, v. 10, n. 1, p. 7628, 2020.

QIU, Shanhu et al. Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis. Cardiovascular diabetology, v. 17, p. 1-12, 2018.

SIXT, Sebastian et al. Long-but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease. European heart journal, v. 31, n. 1, p. 112-119, 2010.

THIJSSEN, Dick HJ et al. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. European heart journal, v. 40, n. 30, p. 2534-2547, 2019.

VEAR, Natalie K. et al. Efficacy of exercise training for improving vascular dysfunction in people with cancer: a systematic review with meta-analyses. Journal of Cancer Survivorship, p. 1-16, 2023.

WANG, Zhipeng et al. Higher risk of cardiovascular mortality than cancer mortality among long-term cancer survivors. Frontiers in Cardiovascular Medicine, v. 10, p. 1014400, 2023.

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Publicado

2024-11-02

Como Citar

Santos, C. C. dos ., Santos e Santos , T. B., Andrade Ferreira de Souza, J., Santana e Silva, M. M., Miranda dos Santos, A., de Fátima Dornelas de Andrade , A., & Cunha Brandão, D. (2024). Treinamento físico na melhora da função endotelial de mulheres com câncer de mama: uma revisão sistemática. Peer Review, 6(17), 260–274. https://doi.org/10.53660/PRW-2672-4827

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