Impact of COVID-19 severity on sleep parameters, exercise tolerance, respiratory muscle strength, pulmonary function, and quality of life: a cross-sectional study
DOI:
https://doi.org/10.53660/PRW-2635-4803Palavras-chave:
Exercise tolerance, Sleep quality, Long-COVID-19, Quality of life, Lung functionResumo
To investigate the impact of post-COVID-19 infection severity on lung function, exercise tolerance, sleep parameters, and quality of life. A cross-sectional study with 30 individuals (age 44.27±14.88 years; 70% women) affected by COVID-19 (23.37±3.49 months after acute infection) was divided into 3 groups: control, mild, and moderate/severe. Evaluations included: submaximal aerobic capacity, respiratory muscle strength, lung function, sleep parameters and quality of life. The moderate/severe group showed lower results for the predicted percentage of FEV1/FVC (p=0.004) and significant differences in sustained maximum inspiratory pressure (SMIP) and fatigue index (FIT) (p<0.05). They also showed reduced exercise tolerance with shorter walking distances (p<0.001), poorer sleep quality, excessive daytime sleepiness, lower sleep efficiency (p=0.032), longer sleep latency (p<0.001), and more awakenings (p=0.006). Quality of life was reduced in three of the eight domains assessed. Individuals with moderate/severe COVID-19 exhibited impaired pulmonary function, reduced sleep efficiency, more awakenings, and lower quality of life compared to those with asymptomatic or mild cases.
Downloads
Referências
AHMED, H. et al. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis. Journal of Rehabilitation Medicine, v. 52, p. 5, 2020. Disponível em: https://doi.org/10.2340/16501977-2694.
AMERICAN THORACIC SOCIETY; EUROPEAN RESPIRATORY SOCIETY. ATS/ERS statement on respiratory muscle testing. American Journal of Respiratory and Critical Care Medicine, v. 166, p. 518-624, 2002.
APPEL, K. S. et al. Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON). Infection, v. 8, p. 2226-2229, 2024. Disponível em: https://doi.org/10.1007/s15010-024-02226-9.
BERTOLAZI, N. A. et al. Validação da escala de sonolência de Epworth em português para uso no Brasil. Jornal Brasileiro de Pneumologia, v. 35, p. 877–883, 2009. Disponível em: https://doi.org/10.1590/S1806-37132009000900009.
BERTOLAZI, N. A.; BARRETO, S. S. M. Tradução, adaptação cultural e validação de dois instrumentos de avaliação do sono: escala de sonolência de Epworth e índice de qualidade de sono de Pittsburgh. 2008. Dissertação (Mestrado) – Universidade Federal do Rio Grande do Sul, Porto Alegre, 2008.
BESNIER, F. et al. Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study. International Journal of Environmental Research and Public Health, v. 19, n. 7, p. 4133, 2022. Disponível em: https://doi.org/10.3390/ijerph19074133.
BRITTO, R. R. et al. Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Brazilian Journal of Physical Therapy, v. 6, p. 556-563, 2014. Disponível em: http://dx.doi.org/10.1590/S1413-35552012005000122.
CICONELLI, R. M. et al. Tradução para a língua portuguesa e validação do questionário genérico de qualidade de vida SF-36 (Brasil SF-36). Revista Brasileira de Reumatologia, v. 39, p. 143-150, 1999. Disponível em: https://doi.org/10.1097/00005131-200609001-00005.
CRAPO, R. O. et al. American thoracic society ATS statement: Guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, v. 166, p. 111–117, 2002. Disponível em: https://doi.org/10.1164/rccm.166/1/111.
DAYNES, E. et al. Early experiences of rehabilitation for individuals post-COVID to improve fatigue, breathlessness exercise capacity and cognition - A cohort study. Chronic Respiratory Disease, v. 18, p. 147, 2021. Disponível em: https://doi.org/10.1177/14799731211015691.
DUARTE, A. A. O.; CRAPO, C. A. C.; RODRIGUES, S. C. S. Validação de novos valores previstos brasileiros para a espirometria forçada na raça branca e comparação com os valores previstos obtidos por outras equações de referência. Jornal Brasileiro de Pneumologia, v. 33, p. 527-535, 2007. Disponível em: https://doi.org/10.1590/S1806-37132007000500007.
FORMIGA, M. F. et al. Beyond inspiratory muscle strength: Clinical utility of single-breath work capacity assessment in veterans with COPD. Respiratory Medicine, v. 147, p. 13-18, 2019. Disponível em: https://doi.org/10.1016/j.rmed.2018.12.012.
HERRIDGE, M. S. et al. Functional disability 5 years after acute respiratory distress syndrome. New England Journal of Medicine, v. 364, p. 1293-1304, 2011. Disponível em: https://doi.org/10.1056/NEJMoa1011802.
JACOBS, L. G. et al. Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS One, v. 15, p. e0243882, 2021. Disponível em: https://doi.org/10.1371/journal.pone.0243882.
KRESS, J. P.; HALL, J. B. ICU-acquired weakness and recovery from critical illness. New England Journal of Medicine, v. 370, p. 1626-1635, 2014. Disponível em: https://doi.org/10.1056/NEJMra1209390.
LIU, K. et al. Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study. Complementary Therapies in Clinical Practice, v. 39, p. 101166, 2020. Disponível em: https://doi.org/10.1016/j.ctcp.2020.101166.
MORROW, A. et al. Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21. Trials, v. 23, p. 660, 2022. Disponível em: https://doi.org/10.1186/s13063-022-06632-y.
NAKANISHI, T. et al. Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Journal of Clinical Investigation, v. 131, p. e152386, 2021. Disponível em: https://doi.org/10.1172/JCI152386.
NOPP, S. et al. Outpatient Pulmonary Rehabilitation in Patients with Long COVID Improves Exercise Capacity, Functional Status, Dyspnea, Fatigue, and Quality of Life. Respiration, v. 101, p. 593-601, 2022. Disponível em: https://doi.org/10.1159/000522118.
NOWAKOWSKI, S. et al. Association between Sleep Quality and Mental Health among Patients at a Post-COVID-19 Recovery Clinic. Brain Sciences, v. 30, p. 586, 2022. Disponível em: https://doi.org/10.3390/brainsci12050586.
OJO, A. S. et al. Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies. Pulmonary Medicine, v. 106, p. 175964, 2020. Disponível em: https://doi.org/10.1155/2020/6175964.
ÖZLÜ, I. et al. The effects of progressive muscle relaxation exercises on the anxiety and sleep quality of patients with COVID-19: A randomized controlled study. Perspectives in Psychiatric Care, v. 57, p. 1791-1797, 2021. Disponível em: https://doi.org/10.1111/ppc.12750.
PARASHER, A. COVID-19: compreensão atual de sua fisiopatologia, apresentação clínica e tratamento. Postgraduate Medical Journal, v. 1147, p. 312–320, 2021. Disponível em: https://doi.org/10.1136/postgradmedj-2020-138577.
SEMYACHKINA-GLUSHKOVSKAYA, O. et al. Brain Mechanisms of COVID-19-Sleep Disorders. International Journal of Molecular Sciences, v. 28, p. 6917, 2021. Disponível em: https://doi.org/10.3390/ijms22136917.
SIRAYDER, U. et al. Long-Term Characteristics of Severe COVID-19: Respiratory Function, Functional Capacity, and Quality of Life. International Journal of Environmental Research and Public Health, v. 19, p. 6304, 2022. Disponível em: https://doi.org/10.3390/ijerph19106304.
SOUZA, L. F. F. et al. The impact of COVID-19 pandemic in the quality of sleep by Pittsburgh Sleep Quality Index: A systematic review. Ciência & Saúde Coletiva, v. 26, p. 1457-1466, 2021. Disponível em: https://doi.org/10.1590/1413-81232021264.45952020.
TANRIVERDI, A. et al. Extrapulmonary features of post-COVID-19 patients: muscle function, physical activity, mood, and sleep quality. Irish Journal of Medical Science, v. 191, p. 969-975, 2022. Disponível em: https://doi.org/10.1007/s11845-021-02667-3.
ZHAN, Y. et al. SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection. Signal Transduction and Targeted Therapy, v. 6, p. 368, 2021. Disponível em: https://doi.org/10.1038/s41392-021-00777-z.
