Potencial da suplementação alimentar de caprinos com potássio, sódio e silício via pó de rocha na prevenção e controle da mastite subclínica: uma análise bioinformática
Resumo
A mastite caprina é um problema comum, mesmo em criações bem manejadas, e a implementação de medidas de controle é essencial para garantir a viabilidade desse tipo de produção. Nesse contexto, este estudo tem por objetivo avaliar as possíveis contribuições dos componentes minerais do pó de rocha, no controle e prevenção da mastite subclínica em caprinos. Foi realizada análise bioinformática, utilizando a base de dados Search Tool for Interactions of Chemicals STITCH. Para isso, os elementos potássio, sódio e silício, juntamente com as proteínas ica (A, B, C, D), foram inseridos na plataforma para a construção da rede de interação proteica. Os resultados indicaram que o potássio atua na enzima Guanilato quinase, relacionada à formação de biofilmes, e da proteína murB, associada ao crescimento e desenvolvimento do Staphylococcus caprae. No entanto, este mineral demonstrou potencial em desfavorecer o crescimento bacteriano, inibindo a proteína asd. O sódio mostrou-se como fator inibitório para a formação de biofilmes via proteína tmk. O silício, por sua vez, pode colaborar com atenuação do processo infecioso por intermédio das moléculas de sódio e potássio, reduzindo níveis de glicose que desfavorece a formação de biofilmes e ainda atuando em proteínas como a pgi, que se inibida pode prejudicar o desenvolvimento do S. caprae.
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