Atividade antifúgica do eugenol sobre a Candida tropicalis
Resumo
O objetivo deste estudo foi avaliar o efeito antifúngico do eugenol sobre cepas de Candida tropicalis isoladas da cavidade bucal de indivíduos. Trata-se de um estudo in vitro com coleta do material biológico para isolamento e identificação de espécies de Candida foi realizado por três swabs estéreis. Cada swab foi umedecido em solução salina 0,9% esterilizada e aplicado em três sítios distintos da cavidade bucal: palato duro, língua e mucosa jugal do paciente com movimentos de vai e vêm (fricção), por 30 segundos, em cada sítio anatômico. Os resultados demonstraram que a CIM do eugenol foi de 64
Downloads
Referências
AHMAD, A. et al. In vitro synergy of eugenol and methyleugenol with fluconazole against clinical Candida isolates. Journal of Medical Microbiology. v. 59, v. 10, p. 1178–1184.
ALEM, M. A.; DOUGLAS, L. J. et al. Effects of aspirin and other nonsteroidal anti- inflammatory drugs on biofilms and planktonic cells of Candida albicans. Antimicrobial Agents and Chemotherapy. v. 48, n. 1, p. 41–47. 2004.
BORSATO, D. M. et al. Atividade antimicrobiana de méis produzidos por meliponíneos nativos do Paraná. Boletim do Centro de Pesquisar de Processamento de Alimentos. v. 31,
p. 57-66. 2013.
BRAGA, P. C. et al. Thymol inhibits Candida albicans biofilm formation and mature biofilm.
International Journal of Antimicrobial Agents. v. 31, n. 5, p. 472-477. 2008.
EGGIMANN, P.; GARBINO, J.; PITTE D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infectious Dis. v. 3, n. 11, p. 685-702. 2003.
ESPINEL-INGROFF, A. et al. Optimal testing coditions for determining MICs and minimum fungicidal concentrations of new and established antifungal agents for uncommon molds: NCCLS collaborative study. Journal of Clinical Microbiology. v. 40, n. 10, p. 3776-3781.
FONTENELLE, R. O. S. et al. Alkylphenol Activity against Candida spp. and Microsporum canis: A Focus on the Antifungal Activity of Thymol, Eugenol and O-Methyl Derivatives.
Molecules. v. 16, n. 8, p. 6422-6431. 2011.
GAYOSO, C.W. et al. Sensitivity of fungi isolated from onychomycosis to Eugenia cariophyllata essential oil and eugenol. Fitoterapia. v. 76, n. 2, p. 247–249. 2005
HARRIS, R. Progress with superficial mycoses using essential oils. International Journal Aromather. v. 12, p. 83–91. 2002.
HE, M. et al. In vitro activity of eugenol against Candida albicans biofilm. Mycopathologia.
v. 163, n. 3, p. 137-143. 2007.
HOOG, G. S.; GUARRO, J. Atlas of clinical fungi. Central bureau voorschimm el cultures.Virgii: Universitant Rovira; 1995.
IOSIF, L. et al. Clinical study on thermography, as modern investigation method for Candida- associated denture stomatitis. Romanian Journal of Morphology and Embryology. v. 57, n. 1, p. 191–195. 2016.
KARAPINAR, M. Inhibitory effects of anethole and eugenol on the growth and toxin production of Aspergillus parasiticus. International Journal of Food Microbiology. v. 10, p. 193–199. 1990.
KHAN, A. et al. Antifungal activities of Ocimum sanctum essential oil and its lead molecules. Natural Product Communication. v. 5, n. 2, p. 345–349. 2010.
KURTZMANN, C. P.; FELL, J. W. The yeast: a taxonomic study. 4. ed. New York: Elsevier; 1998.
LODDER I. The Yeast: a Taxonomic study. Amsterdam: Horth Helland Publishing; 1970.
MARCOS-ARIAS, C. et al. In vitro activities of natural products against oral Candida isolates from denture wearers. BMC Complementary and Alternative Medicine. v. 11,
n.119. 2011.
MILLER, A. B. et al. The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants. Pharmaceutical Biology. v. 53, n. 4, p. 548-554. 2105.
MUSTHAFA, K. S. et al. Antifungal potential of eugenyl acetate against clinical isolates of Candida species. Microbial Pathogenesis. v. 99, p. 19-29. 2016.
NEGRI, M. et al. Early state research on antifungal natural products. Molecules v. 19, n. 3, p. 2925-2956. 2014.
PINTO, E. et al. Antifungal activity of the essential oil of Thymus pulegioides on Candida. Aspergillus and dermatophyte species. Journal of Medical Microbiology. v. 55, n. 10, p.1367–1373. 2006.
PINTO, E. et al. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and derma- tophyte species, Journal of Medical Microbiology. v. 58,
n. 11, p. 1454-1462. 2009.
SIDRIM, J. J. C.; ROCHA, M. F. G. Micologia Médica à luz de autores contemporâneos.
Rio de Janeiro: Ed. Guanabara; 2004.
SIDDIQUI, Z. N. et al. Synthesis, characterization and antimicrobial evaluation of novel halopyrazole derivatives. Journal of Saudi Chemical Society. v. 17, n. 2, p. 237-243. 2013.
SILVA, C. B. et al. Antifungal activity of the lemongrass oil and citral against Candida spp.
Brazilian Journal of Infectious Diseases. v. 12, n. 1, p. 63-66. 2008.
TAMPIERI, M. P. et al. The inhibition of Candida albicans by selected essential oils and their major components. Mycopathologia. v. 159, n. 3, p. 339-345. 2005.