Pharmacological potential of Fridericia Chica: traditional knowledge and chemical composition

Autores

DOI:

https://doi.org/10.53660/PRW-1788-3421

Palavras-chave:

Medicinal Plants, Anti-Inflammatory, Crajiru, Pharmacological Potential

Resumo

The Fridericia chica is a shrub widely distributed throughout the Brazilian territory. In traditional knowledge, it is used for various pathologies. It is a plant of interest in phytotherapy as it is part of the National List of Medicinal Plants of Interest to the Brazilian Unified Health System – RENISUS. Among the scientific studies conducted, the potential antioxidant, analgesic, anti-inflammatory, immunomodulatory, healing, gastroprotective, antibacterial, antifungal, antiprotozoal, antiviral, antitumor, antiangiogenic, photoprotective, diuretic, and hepatoprotective properties have been demonstrated. Furthermore, the assays report the low toxicity of the extracts. Therefore, Fridericia chica is a plant with pharmacological potential for the development of new medications. This article contributes to the dissemination of the species' pharmacological potential and the imminent observation of traditional knowledge.

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Biografia do Autor

José Pereira de Moura Neto, Universidade Federal do Amazonas

Graduado em Farmácia e Especialização em Bioquímica Clínica pela UFBA; Mestrado em Biologia Celular e Molecular pela FIOCRUZ-RJ; Doutorado e Pós-Doutorado em Biotecnologia e Medicina Investigativa (FIOCRUZ); Fellowship Doutorado em Hematology, Oncology and Human Genetics - Boston University, BU- Boston Medical Center - Boston, EUA. Possui experiência nas áreas de Bioquímica e Hematologia Clínica, Biologia Celular e Molecular com ênfase em Genética Humana e Clínica, atuando principalmente em Marcadores moleculares, Hemoglobinopatias, Linfomas, Leucemias, Rabdomiólise, LÚPUS, Cardiopatias, Estresse Oxidativo, Malária e Leishmaniose.

Referências

ALVAREZ-ORTEGA, N; CABALLERO-GALLARDO, K; TABOADA-ALQUERQUE, M et al. Protective effects of the hydroethanolic extract of fridericia chica on undifferentiated human neuroblastoma cells exposed to α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL). Toxins, v. 13, n. 11, 1 nov. 2021.

ALVAREZ-ORTEGA, N; CABALLERO-GALLARDO, K; JUAN, C et al. Cytoprotective, Antiproliferative, and Anti-Oxidant Potential of the Hydroethanolic Extract of Fridericia chica Leaves on Human Cancer Cell Lines Exposed to α- and β-Zearalenol. Toxins, v. 15, n. 1, 1 jan. 2023.

ALVES, M. S. M.; MENDES, P. C.; VIEIRA, J. G. P. et al. Análise farmacognóstica das folhas de Arrabidaea chica (Humb. & Bonpl.) B. Verlt. Bignoniaceae. Brazilian Journal of Pharmacognosy, v. 20, n. 2, p. 215–221, 2010.

ARO, A. A.; FREITAS, K. M.; FOGLIO, M. A. et al. Effect of the Arrabidaea chica extract on collagen fiber organization during healing of partially transected tendon. Life Sciences, v. 92, n. 13, p. 799–807, 19 abr. 2013.

BARBOSA, W. L. R.; PINTO, L. N.; QUIGNARD, E. et al. Arrabidaea chica (HBK) Verlot: Phytochemical approach, antifungal and trypanocidal activities. Brazilian Journal of Pharmacognosy, v. 18, n. 4, p. 544–548, out. 2008.

BATALHA, A. D. DE S. J.; SOUZA, D. C. M.; UBIERA, R. D. et al. Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action. BiomoleculesMDPI, 1 set. 2022.

BIESKI, I. G. C.; LEONTI, M.; ARNASON, J. T. et al. Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil. Journal of Ethnopharmacology, v. 173, p. 383–423, 15 set. 2015.

BRANDÃO, D. C.; LIMA, P. M A P; MARTINS, I. C. et al. Arrabidaea chica chloroform extract modulates estrogen and androgen receptors on luminal breast cancer cells. BMC Complementary Medicine and Therapies, 2022.

BEHRENS, M. D. B.; Tellis, C. J. M.; CHAGAS, M. S. Arrabidaea chica MONOGRAFIA / MONOGRAPHY. p. Revista Fitos, Vol. & no04, dez. 2012.

COE, F. G.; PARIKH, D. M.; JOHNSON, C. A. Alkaloid presence and brine shrimp (Artemia salina) bioassay of medicinal species of eastern Nicaragua. Pharmaceutical Biology, v. 48, n. 4, p. 439–445, 2010.

CORTEZ DE SÁ, J.; ALMEIDA-SOUZA, F.; MONDÊGO-OLIVEIRA, R. et al. Leishmanicidal, cytotoxicity and wound healing potential of Arrabidaea chica Verlot. BMC Complementary and Alternative Medicine, v. 16, n. 1, 4 jan. 2016.

DA CRUZ, A. F. G.; REIS, A. C. C.; SOUSA, J. A. C. et al. High-Resolution Mass Spectrometry Identification and Characterization of Flavonoids from Fridericia chica Leaves Extract with Anti-Arbovirus Activity. Molecules, v. 27, n. 18, 1 set. 2022.

DE SIQUEIRA, F. C.; BARBOSA-CARVALHO, A. P. P.; COSTA LEITÃO, D. S. T. et al. Scavenging Capacity of Extracts of Arrabidaea chica Leaves from the Amazonia against ROS and RNS of Physiological and Food Relevance. Antioxidants, v. 11, n. 10, p. 1909, 27 set. 2022.

DE SOUZA, A. S.; PAGADIGORRIA, C. L. S.; ISHII-IWAMOTO, E. L. et al. Effects of the Arrabidaea chica extract on energy metabolism in the rat liver. Pharmaceutical Biology, v. 47, n. 2, p. 154–161, 2009.

DEVIA, B.; LLABRES, G.; WOUTERS, J. et al. New 3-deoxyanthocyanidins from leaves of Arrabidaea chica. Phytochemical Analysis, v. 13, n. 2, p. 114–120, 2002.

DOS SANTOS, M. I. R.; DE OLIVEIRA SOARES, A.; ARAÚJO, L. M. et al. Determination of Cu, Fe, Mn, and Zn in the leaves and tea of arrabidaea chica (Humb. & Bompl.) Verl. Biological Trace Element Research, v. 132, n. 1–3, p. 239–246, 2009.

DOS SANTOS, V. C.; LONGO, T. B.; GARCIA, A. L H. et al. Evaluation of the mutagenicity and genotoxicity of Arrabidaea chica Verlot (Bignoneaceae), an Amazon plant with medicinal properties. Journal of toxicology and environmental health. Part A, v. 76, n. 6, p. 381–90, 1 mar. 2013.

EMBRAPA. Crajiru (Arrebidaea chica Verlot). Disponível em: <http://ainfo.cnptia.embrapa.br/digital/bitstream/item/24786/1/folder-crajiru.pdf>. Acesso em: 8 fev. 2021.

EVANGELISTA, S. S.; SAMPAIO, F. C.; PARENTE, R. C. et al. Fitoterápicos na odontologia: Estudo etnobotânico na cidade de Manaus. Revista Brasileira de Plantas Medicinais, v. 15, n. 4, p. 513–519, 2013.

FERREIRA, R. S. R. D. S.; RODRIGUES SARQUIS, Í.; RODRIGUES SARQUIS, I. et al. The Use of Medicinal Plants in the Riverside Community of the Mazagão River in the Brazilian Amazon, Amapá, Brazil: Ethnobotanical and Ethnopharmacological Studies. Evidence-based Complementary and Alternative Medicine, v. 2019, 2019.

Ficha de Espécies - SiBBr. Disponível em: <https://ferramentas.sibbr.gov.br/ficha/bin/view/especie/fridericia_chica#HHabitat2FSubstrato>. Acesso em: 8 fev. 2021.

FIGUEIREDO, F. DE F.; DAMAZO, A. S.; ARUNACHALAM, K. et al. Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. Journal of Ethnopharmacology, v. 309, p. 116338, 12 jun. 2023.

GEMELLI, T. F.; DA SILVA PRADO, L.; SANTOS, F. S. et al. Evaluation of Safety of Arrabidaea chica Verlot (Bignoniaceae), a Plant with Healing Properties. Journal of Toxicology and Environmental Health, Part A, v. 78, n. 18, p. 1170–1180, 17 set. 2015.

GURGEL, R. S.; DE MELO PEREIRA, D. Í.; GARCIA, A. V. F. et al. Antimicrobial and Antioxidant Activities of Endophytic Fungi Associated with Arrabidaea chica (Bignoniaceae). Journal of Fungi, v. 9, n. 8, 1 ago. 2023.

HÖFLING, J.F.; ANIBAL, P.C.; OBANDO-PEREDA, G.A. et al. Antimicrobial potential of some plant extracts against Candida species. Brazilian Journal of Biology, v. 70, n. 4, p. 1065–1068, 2010.

JORGE, M. P.; MADJAROF, C.; RUIZ, A. L. T. G. et al. Evaluation of wound healing properties of Arrabidaea chica Verlot extract. Journal of Ethnopharmacology, v. 118, n. 3, p. 361–366, 13 ago. 2008.

JORGE, M. P.; MARIA, P.; ZAGO, W. et al. Clinical Safety Evaluation of an Herbal Gel Containing 2.5% Arrabidaea chica Verlot Standardized Extract. Clinical case Reports international, v. 4, n. 1, p. 12–14, 2020.

LIMA DE MEDEIROS, B.; DOS SANTOS COSTA, K.; RIBEIRO, J. F. A. et al. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). Pharmacognosy Research, v. 3, n. 2, p. 79–84, abr. 2011.

LIMA, F. C. V. M.; OLIVEIRA, A.; LOPES, A. J. O. et al. Effect of Arrabidaea Chica Verlot on Posttraumatic Neuropathic Pain in Rats. Neurodegenerative Diseases: Current Research, v. 2, n. 1, 18 out. 2022a.

LIMA, J. C. S.; DE OLIVEIRA, R. G.; SILVA, V. C. et al. Anti-inflammatory activity of 4′,6,7-trihydroxy-5-methoxyflavone from Fridericia chica (Bonpl.) L.G.Lohmann. Natural Product Research, v. 34, n. 5, p. 726–730, 2020.

LIMA, L. L.; TAKETA, T. B.; BEPPU, M. M et al. Coated electrospun bioactive wound dressings: Mechanical properties and ability to control lesion microenvironment. Materials Science and Engineering C, v. 100, p. 493–504, 1 jul. 2019.

LIMA, W. G.; ARAÚJO, M. G. F.; BRITO, J. C. M. et al. Antifungal effect of hydroethanolic extract of Fridericia chica (Bonpl.) L. G. Lohmann leaves and its therapeutic use in a vulvovaginal candidosis model. Journal of Medical Mycology, v. 32, n. 3, p. 101255, 1 ago. 2022b.

LOPES, G. F. M.; LIMA, W. G.; SANTOS, F. R. S. et al. Anti-Mayaro virus activity of a hydroethanolic extract from Fridericia chica (Bonpl.) L. G. Lohmann leaves. Journal of Ethnopharmacology, v. 299, p. 115685, 2022.

MAFIOLETI, L.; DA SILVA JUNIOR, I. F.; COLODEL, E. M. et al. Evaluation of the toxicity and antimicrobial activity of hydroethanolic extract of Arrabidaea chica (Humb. & Bonpl.) B. Verl. Journal of Ethnopharmacology, v. 150, n. 2, p. 576–582, 25 nov. 2013.

MARTINS, A. S.; ALVES, C. N.; LAMEIRA, O. A. et al. Avaliação de minerais em plantas medicinais amazônicas. Revista Brasileira de Farmacognosia, v. 19, n. 2b, p. 621–625, 2009.

MARTINS, F. J.; CANESCHI, C. A.; VIEIRA, J. L.F. et al. Antioxidant activity and potential photoprotective from amazon native flora extracts. Journal of Photochemistry and Photobiology B: Biology, v. 161, p. 34–39, 1 ago. 2016.

MICHEL, A. F. R. M.; MELO, M. M.; CAMPOS, P. P. et al. Evaluation of anti-inflammatory, antiangiogenic and antiproliferative activities of Arrabidaea chica crude extracts. Journal of Ethnopharmacology, v. 165, p. 29–38, 13 maio 2015.

MISSOURI. Tropicos.org. Missouri Botanical Garden. Disponível em: <https://tropicos.org/name/Search?name=Arrabidaea chica>. Acesso em: 8 fev. 2021.

OLIVEIRA, D. P. C.; BORRÁS, M. R. L.; FERREIRA, L. C. L. et al. Atividade antiinflamatória do extrato aquoso de Arrabidaea chica (Humb. & Bonpl.) B. Verl. sobre o edema induzido por venenos de serpentes amazônicas. Revista Brasileira de Farmacognosia, v. 19, n. 2b, p. 643–649, 2009.

OLIVERO-VERBEL, J.; DE LA PARRA-GUERRA, A.; CABALLERO-GALLARDO, K. et al. The aqueous extract of Fridericia chica grown in northern Colombia ameliorates toxicity induced by Tergitol on Caenorhabditis elegans. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 244, p. 109026, 2021.

PAULA, J. T.; PAVIANI, L. C.; FOGLIO, M. A. et al. Extraction of anthocyanins and luteolin from Arrabidaea chica by sequential extraction in fixed bed using supercritical CO2, ethanol and water as solvents. Journal of Supercritical Fluids, v. 86, p. 100–107, 1 fev. 2014.

PEDROZA, M. et al. ATIVIDADE CICATRIZANTE DE MICROENCAPSULADOS DE EXTRATO BRUTO ETANÓLICO OBTIDO DE Arrabidaea chica (HUMB. & BONPL.) VERLOT. [s.l: s.n.]. . Acesso em: 8 abr. 2020.

QUEIROZ, DE S. H.; DE FREITAS, H. A.; CÉLI, O M. C. F. Preparo do corante de crajirú (Arrabidaea chica (Bonpl.) B. Verl.) e sua aplicação em Histologia. [s.l: s.n.]. . Acesso em: 15 fev. 2021.

QUEIROZ, N. D. C. A.; JORGE, M. P.; SOUSA, I. M. O et al. Arrabidaea chica for oral mucositis in patients with head and neck cancer: A protocol of a randomised clinical trial. BMJ Open, v. 8, n. 10, p. 6–10, 2018.

DO AMARAL, R. R.; SANTOS, A. A.D; SARAIVA, A. et al. Biological Activities of Arrabidaea chica (Bonpl.) B. Verl. Leaves. Disponível em: <https://www.researchgate.net/publication/274836479_Biological_Activities_of_Arrabidaea_chica_Bonpl_B_Verl_Leaves>. Acesso em: 22 jun. 2020.

RIBEIRO, A. F. C.; TELLES, T. C.; FERRAZ, V. P. et al. Effect of Arrabidaea chica extracts on the Ehrlich solid tumor development. Brazilian Journal of Pharmacognosy, v. 22, n. 2, p. 364–373, 2012.

ROCHA, K. B. F.; OLIVEIRA, C. N.; AZEVEDO, Í. M. et al. Effect of arrabidaea chica extract against chemically induced breast cancer in animal model. Acta Cirurgica Brasileira, v. 34, n. 10, 1 out. 2019.

SALLES, T. H. C.; VOLPE-ZANUTTO, F.; DE OLIVEIRA SOUSA, I. M. et al. Electrospun PCL-based nanofibers Arrabidaea chica Verlot – Pterodon pubescens Benth loaded: synergic effect in fibroblast formation. Biomedical Materials, v. 15, n. 6, p. 065001, 3 set. 2020.

SCHIOZER, A. L.; MARÇO, P. H.; BARATA, L. E.S. et al. Exploratory analysis of Arrabidaea chica deoxyanthocyanidins using chemometric methods. Analytical Letters, v. 41, n. 9, p. 1592–1602, 2008.

SCHIOZER, A. L.; CABRAL, E. C.; DE GODOY, L. A.F. et al. Electrospray ionization mass spectrometry fingerprinting of extracts of the leaves of Arrabidaea chica. Journal of the Brazilian Chemical Society, v. 23, n. 3, p. 409–414, 2012.

SERVAT-MEDINA, L.; GONZÁLEZ-GÓMEZ, A.; REYES-ORTEGA, F. et al. Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: Synthesis, characterization, biocompatibility, and antiulcerogenic activity. International Journal of Nanomedicine, v. 10, p. 3897–3909, 2015.

SIRAICHI, J. T. G.; PEDROCHI, F.; NATALI, M. R M et al. Ultraviolet (UVB and UVA) Photoprotector Activity and Percutaneous Penetration of Extracts Obtained from Arrabidaea chica. Applied Spectroscopy, v. 67, n. 10, p. 1179–1184, 2013a.

SIRAICHI, J. T. G.; FELIPE, D. F.; BRAMBILLA, L. Z. S. et al. Antioxidant Capacity of the Leaf Extract Obtained from Arrabidaea chica Cultivated in Southern Brazil. PLoS ONE, v. 8, n. 8, 29 ago. 2013b.

SOUSA. AVALIAÇÃO DA ESTABILIDADE DO EXTRATO SECO E FORMULAÇÕES DE BASES SEMI SÓLIDAS, CONTENDO ARRABIDAEA CHICA VERLOT, PARA USO. [s.l: s.n.]. . Acesso em: 8 abr. 2020.

SOUSA IMO; RIVERA, G.A.; PINT, D. et al. The role of spray-drying atmosphere on fridericia chica (bonpl.) L.G. Lohmann standardized extract production for wound healing activity. Nat Prod Res., 22DC.

TAFFARELLO, D.; JORGE, M. P.; DE OLIVEIRA SOUSA, I. M. et al. Atividade de extratos DE Arrabidaea chica (HUMB. & BONPL.) VERLOT OBTIDOS POR PROCESSOS BIOTECNOLÓGICOS SOBRE A PROLIFERAÇÃO DE FIBROBLASTOS E CÉLULAS TUMORAIS HUMANAS. Quimica Nova, v. 36, n. 3, p. 431–436, 2013.

TORRES, C. A.; PÉREZ ZAMORA, C. M.; NUÑEZ, M. B. et al. In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae. Journal of Integrative Medicine, v. 16, n. 4, p. 255–262, 1 jul. 2018.

VASCONCELOS, C. C.; LOPES, A. J. O.; SOUSA, E. L. F. et al. Effects of extract of arrabidaea chica verlot on an experimental model of osteoarthritis. International Journal of Molecular Sciences, v. 20, n. 19, 1 out. 2019.

VIOLANTE I.M.P., CAROLLO, C.A.; SILVA, L.I. et al. Cytotoxicity and antibacterial activity of scutellarein and carajurone-enriched fraction obtained from the hydroethanolic extract of the leaves of Fridericia chica (Bonpl.) L.G. Lohmann. Nat Prod Res., 2021.

ZAGO, P. M. W.; SOUSA, I. M. O.; SERVAT-MEDINA, L. et al. Standardized arrabidaea chica extract shows cytoprotective effects in zoledronic acid-treated fibroblasts and osteoblasts. Clinical, Cosmetic and Investigational Dentistry, v. 12, p. 327–333, 2020.

ZORN, B.; GARCÍA-PIÑERES, A. J.; CASTRO, V. et al. 3-Desoxyanthocyanidins from Arrabidaea chica. Phytochemistry, v. 56, n. 8, p. 831–835, 12 abr. 2001.

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2024-02-10

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Jamel, A. S. ., Moura Neto, J. P. de, de Paula, E. V. ., Alexandre, C. N. ., Queiroz, N. de C. A. ., & Foglio, M. A. . (2024). Pharmacological potential of Fridericia Chica: traditional knowledge and chemical composition. Peer Review, 6(3), 17–35. https://doi.org/10.53660/PRW-1788-3421

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