Synthesis and characterization of copper (I) particles as contrast agents in magnetic resonance imaging
Palavras-chave:
Multiple sclerosis, MRI, biomarker, contrast agent, copperResumo
Recent studies have focused on the link between metals and neurodegenerative diseases like multiple sclerosis (MS), particularly emphasizing the role of copper (Cu). Essential for vital functions, Cu imbalances can contribute to MS-related neurodegeneration and cerebral lesions. Interestingly, Cu accumulation could be a potential biomarker in magnetic resonance image (MRI) for MS. This study aimed to obtain copper(I) oxide nanoparticles (Cu2O-NPs) and evaluate their effectiveness in MRI as contrast agents or MS biomarkers. These nanoparticles were synthesized using the sol-gel method and analyzed via X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). MRI images were obtained introducing Cu2O-NPs into a cranial phantom at various concentrations and inversion times. Results showed that changes in MRI signal and longitudinal relaxation rate (T1) are associated with nanoparticle concentration, highlighting the potential of Cu2O-NPs in MRI applications for MS.
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BOTSA, S.; RAMADEVI, D.; BASAVAIAH, K. A Facile Synthesis of Copper Oxide Nanorods for Photocatalytic Degradation of Organic Pollutant and Inactivation of Pathogens. Journal of Nanoscience and Technology, [s. l.], v. 4, p. 467–470, 2018.
COMPSTON, A.; MCDONALD, I. R.; NOSEWORTHY, J.; LASSMANN, H.; MILLER, D. H.; SMITH, K. J.; WEKERLE, H.; CONFAVREUX, C. McAlpine’s Multiple Sclerosis. 4th editioned. Philadelphia: Churchill Livingstone, 2005. 2005.
DE OLIVEIRA, M.; GIANETI, T. M. R.; DA ROCHA, F. C. G.; LISBOA-FILHO, P. N.; PIACENTI-SILVA, M. A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS. Scientific Reports, [s. l.], v. 10, n. 1, p. 13112, 2020.
DE OLIVEIRA, M.; PIACENTI-SILVA, M.; DA ROCHA, F. C. G.; SANTOS, J. M.; CARDOSO, J. dos S.; LISBOA-FILHO, P. N. Lesion Volume Quantification Using Two Convolutional Neural Networks in MRIs of Multiple Sclerosis Patients. Diagnostics, [s. l.], v. 12, n. 2, p. 230, 2022.
DE RICCARDIS, L.; BUCCOLIERI, A.; MUCI, M.; PITOTTI, E.; DE ROBERTIS, F.; TRIANNI, G.; MANNO, D.; MAFFIA, M. Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, [s. l.], v. 1864, n. 5, Part A, p. 1828–1838, 2018.
ENDRES, S. C.; CIACCHI, L. C.; MÄDLER, L. A review of contact force models between nanoparticles in agglomerates, aggregates, and films. Journal of Aerosol Science, [s. l.], v. 153, p. 105719, 2021.
FERESHTEH, F.; M, G.-C. Metals in Multiple Sclerosis: Improvement or Progression. Global Journal of Nanomedicine, [s. l.], v. 2, n. 2, 2017. Disponível em: https://juniperpublishers.com/gjn/GJN.MS.ID.555581.php. Acesso em: 26 jan. 2024.
GAO, L.; PANG, C.; HE, D.; SHEN, L.; GUPTA, A.; BAO, N. Synthesis of Hierarchical Nanoporous Microstructures via the Kirkendall Effect in Chemical Reduction Process. Scientific Reports, [s. l.], v. 5, n. 1, p. 16061, 2015.
GATES-RECTOR, S.; BLANTON, T. The Powder Diffraction File: a quality materials characterization database. Powder Diffraction, [s. l.], v. 34, n. 4, p. 352–360, 2019.
HESAMIAN, M. S.; ESKANDARI, N. Potential Role of Trace Elements (Al, Cu, Zn, and Se) in Multiple Sclerosis Physiopathology. Neuroimmunomodulation, [s. l.], v. 27, n. 4, p. 163–177, 2020.
JOHNSON, H.; HARRIS, G.; WILLIAMS, K. BRAINSFIT: Mutual information registrations of whole-brain 3D Images, using the insight toolkit. [s. l.], 2007.
KAMPMAN, M. T.; BRUSTAD, M. Vitamin D: A Candidate for the Environmental Effect in Multiple Sclerosis – Observations from Norway. Neuroepidemiology, [s. l.], v. 30, n. 3, p. 140–146, 2008.
KAYANI, Z. N.; UMER, M.; RIAZ, S.; NASEEM, S. Characterization of Copper Oxide Nanoparticles Fabricated by the Sol–Gel Method. Journal of Electronic Materials, [s. l.], v. 44, n. 10, p. 3704–3709, 2015.
LA, P.; LJ, de A. S.; BM, F.; R, E.; JFP, L.; O, P. G.; JH, R.; PN, L.-F.; JA, G.; CA, F.; AFS, B. Effects of ZnO/TiO2 nanoparticle and TiO2 nanotube additions to dense polycrystalline hydroxyapatite bioceramic from bovine bones. Dental Materials : Official Publication of the Academy of Dental Materials, [s. l.], v. 36, n. 2, p. e38–e46, 2019.
LOHRKE, J.; FRENZEL, T.; ENDRIKAT, J.; ALVES, F. C.; GRIST, T. M.; LAW, M.; LEE, J. M.; LEINER, T.; LI, K.-C.; NIKOLAOU, K.; PRINCE, M. R.; SCHILD, H. H.; WEINREB, J. C.; YOSHIKAWA, K.; PIETSCH, H. 25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives. Advances in Therapy, [s. l.], v. 33, n. 1, p. 1–28, 2016.
L. QUE, E.; J. CHANG, C. Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine. Chemical Society Reviews, [s. l.], v. 39, n. 1, p. 51–60, 2010.
MAÑA, P.; FORDHAM, S. A.; STAYKOVA, M. A.; CORRECHA, M.; SILVA, D.; WILLENBORG, D. O.; LIÑARES, D. Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation. Journal of Neuroimmunology, [s. l.], v. 210, n. 1–2, p. 13–21, 2009.
NZILU, D. M.; MADIVOLI, E. S.; MAKHANU, D. S.; WANAKAI, S. I.; KIPRONO, G. K.; KARERU, P. G. Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic. Scientific Reports, [s. l.], v. 13, n. 1, p. 14030, 2023.
OLSSON, T.; BARCELLOS, L. F.; ALFREDSSON, L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nature Reviews Neurology, [s. l.], v. 13, n. 1, p. 25–36, 2017.
PATEL, M.; MISHRA, S.; VERMA, R.; SHIKHA, D. Synthesis of ZnO and CuO nanoparticles via Sol gel method and its characterization by using various technique. Discover Materials, [s. l.], v. 2, n. 1, p. 1, 2022.
SARMADI, M.; BIDEL, Z.; NAJAFI, F.; RAMAKRISHNAN, R.; TEYMOORI, F.; ZARMEHRI, H. A.; NAZARZADEH, M. Copper concentration in multiple sclerosis: a systematic review and meta-analysis. Multiple Sclerosis and Related Disorders, [s. l.], v. 45, p. 102426, 2020.
SHIRKE, B.; KABURE, A. The lpg gas-sensing performance of ceo2-cuo nanocomposite film synthesized by microwave assisted sol-gel method. [s. l.], 2021.
SIMON, J. H.; LI, D.; TRABOULSEE, A.; COYLE, P. K.; ARNOLD, D. L.; BARKHOF, F.; FRANK, J. A.; GROSSMAN, R.; PATY, D. W.; RADUE, E. W. Standardized MR imaging protocol for multiple sclerosis: Consortium of MS Centers consensus guidelines. American Journal of Neuroradiology, [s. l.], v. 27, n. 2, p. 455–461, 2006.
TUSTISON, N. J.; AVANTS, B. B.; COOK, P. A.; ZHENG, Y.; EGAN, A.; YUSHKEVICH, P. A.; GEE, J. C. N4ITK: improved N3 bias correction. IEEE transactions on medical imaging, [s. l.], v. 29, n. 6, p. 1310–1320, 2010.
USHA, V.; KALYANARAMAN, S.; THANGAVEL, R.; VETTUMPERUMAL, R. Effect of catalysts on the synthesis of CuO nanoparticles: Structural and optical properties by sol–gel method. Superlattices and Microstructures, [s. l.], v. 86, p. 203–210, 2015.
VOLANTI, D.; KEYSON, D.; CAVALCANTE, L. S.; SIMÕES, A.; RINCÓN-JOYA, M.; LONGO, E.; VARELA, J.; PIZANI, P.; SOUZA, A. Synthesis and Characterization of CuO Flower-Nanostructure Processing by a Domestic Hydrothermal Microwave. Journal of Alloys and Compounds, [s. l.], v. 459, p. 537–542, 2008.
WAHSNER, J.; GALE, E. M.; RODRÍGUEZ-RODRÍGUEZ, A.; CARAVAN, P. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers. Chemical reviews, [s. l.], v. 119, n. 2, p. 957–1057, 2019.
ZAPAROLI, H. H.; OLIVEIRA, M. de; FILHO, P. N. L.; SILVA, M. P. da. Simulação de lesões de esclerose múltipla em imagens de ressonância magnética utilizando nanopartículas de zinco / Simulation of multiple sclerosis lesions on magnetic resonance Magnetic resonance imaging using zinc nanoparticles. Brazilian Journal of Development, [s. l.], v. 7, n. 9, p. 94624–94637, 2021a.
ZAPAROLI, H. H.; OLIVEIRA, M. de; LISBOA-FILHO, P. N.; PIACENTI-SILVA, M. Utilização de Partículas de Zinco em Fantoma para Simulação de Lesões de Esclerose Múltipla em Imagens de Ressonância Magnética. Revista Brasileira de Física Médica, [s. l.], v. 15, p. 619–619, 2021b.
ZAYYOUN, N.; BAHMAD, L.; LAÂNAB, L.; JABER, B. The effect of pH on the synthesis of stable Cu2O/CuO nanoparticles by sol-gel method in a glycolic medium. Applied Physics A: Materials Science & Processing, [s. l.], v. 122, p. 488, 2016.
ZEDAN, A. F.; ALJABER, A. S. Combustion Synthesis of Non-Precious CuO-CeO₂ Nanocrystalline Catalysts with Enhanced Catalytic Activity for Methane Oxidation. Materials (Basel, Switzerland), [s. l.], v. 12, n. 6, p. E878, 2019.
