Inhibition of nitric oxide synthase modulates learned helplessness response in female rats
DOI:
https://doi.org/10.53660/1537.prw3050Palavras-chave:
Nitric oxide synthase, Depression, Stress, Learned helplessnessResumo
Learned helplessness is the condition of humans or animals that have learned to behave helplessly, failing to respond even though there are opportunities to help themselves by avoiding unpleasant circumstances. It was investigated the participation of nitric oxide (NO) in female Wistar rats in learned helplessness tests. The animals received acute treatment with N–nitro-l-arginine methyl ester (L-NAME, 10 mg/kg or 100 mg/kg), an inhibitor of NO synthase, 30 minutes before random inescapable shock sessions lasting 25 minutes. On the test day, the animals that received L-NAME of 10 mg/kg or 100 mg/kg 24 hours beforehand, demonstrated reduced difference between stress and non-stress groups compared with control groups. The activity of the neuronal nitric oxide synthase was lower in animals pretreated with L-NAME, especially at a dose of 100 mg/kg. These results indicate that acute inhibition of NO synthase improved learned helplessness response, suggesting that NO is involved with stress and depression.
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